Black FridayDealsBuying guidesBrandsStoresTermsPrivacydeal.ai apps

© Deal.ai Inc.

Deal.ai
Bayer
Bayer Advantage II Flea Prevention for Dogs

Bayer Advantage II Flea Prevention for Dogs

3.6· 75 ratings

Best price now

$50.99at Chewy.comObserved at 5:09 AM

Compared across 4 stores. Prices are checked against each store and labelled with when.

Visit Chewy.com

Ask our shopping agent

Enter to send, Shift+Enter for a new line

Our take on the Bayer Advantage II Flea Prevention for Dogs

Advantage II is a monthly spot-on flea treatment for dogs 21-55 lbs. It uses imidacloprid to kill adult fleas and pyriproxyfen to stop eggs and larvae from developing, so it breaks the flea life cycle rather than just killing what is on the dog. It is fragrance-free, waterproof after 24 hours, and needs no prescription. The best new price is $50.99 at Chewy.com as of November 4, 2026, for a 4-month supply; four stores carry it new.

Best forOwners of dogs 21-55 lbs with an active flea problemHouseholds that want a no-prescription monthly topicalMulti-dog homes needing a 4-month supplyDogs that swim or get bathed often
Pros
  • Kills adult fleas within 12 hours of application
  • Pyriproxyfen stops eggs and larvae, breaking the life cycle
  • Fragrance-free and waterproof after 24 hours
  • No vet visit or prescription needed
  • Four monthly doses per box
Cons
  • Only for dogs 21-55 lbs; other sizes sold separately
  • Toxic to cats, so cats in the home must be kept away
  • Monthly reapplication required; it does not repel fleas
  • Does not treat ticks or mites
  • Some dogs show skin irritation at the application site

Bayer Advantage II Flea Prevention for Dogs prices at every store

  • Chewy.comNew

    In stock

    $50.99Free shippingObserved at 5:09 AM
    Visit store
  • PetSmartNew

    In stock

    $52.99+ $6.99 shippingObserved at 5:09 AM
    Visit store
  • Centinela Feed & Pet SuppliesNew

    In stock

    $55.99+ $6.99 shippingObserved at 5:09 AM
    Visit store
  • DoMyOwn.comNew

    In stock

    $65.91Free shippingObserved at 5:09 AM
    Visit store

Also available at

  • AmazonCheck price at Amazon
  • WalmartCheck price at Walmart

Bayer Advantage II Flea Prevention for Dogs price history

Lowest price we've seen: $50.99 on Nov 4 at Chewy.com. Tracked across 6 stores since Nov 4.

What reviewers say

Owners generally find Advantage II effective at clearing fleas and easy to apply, and many like that it is fragrance-free. The 3.6 out of 5 from 75 ratings reflects complaints about irritation at the spot and about fleas returning when doses are missed.

Pros
  • Clears fleas quickly, often within a day
  • Easy spot-on application
  • No strong smell
  • Works well alongside home cleaning
Cons
  • Skin irritation or hair loss at the application spot
  • Fleas come back if a monthly dose is skipped
  • Price per dose is higher than some oral options
  • Not effective against ticks

From PetSmart

  • Vet-recommended flea prevention and treatment for dogs 21-55 lbs
  • Kills adult fleas, flea larvae and flea eggs for total flea protection
  • Kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical spot-on treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours
  • Breaks the flea life cycle, controlling existing flea and lice infestations
Sizes
2 Count, 4 Count, 6 Count
Sizing
For dogs weighing 21 to 55 lbs and at least 7 weeks old
Shipping
Free Same-Day Delivery, no order minimum; free shipping over a threshold for signed-in members
Packs
2 Count, 4 Count and 6 Count
In the box
4 Month Supply

About the Bayer Advantage II Flea Prevention for Dogs

Advantage® II Flea Prevention & Treatment for Large Dogs 21-55 lbs, Monthly Doses

Specifications

Targeted Pests
Fleas
Active Ingredient
Imidacloprid, Pyriproxyfen
Administration Method
Topical, Topical treatment, Topical application
Life Stage Age
At least 7 weeks of age
Treatment Frequency
Monthly
Dosage Concentration
0.46% (Pyriproxyfen)
Dosage Duration
30 days

Questions and answers

Is Advantage II worth it over a chewable flea pill?
Advantage II is a solid choice if you want a no-prescription topical that also kills eggs and larvae. Oral pills like Bravecto or NexGard last longer and cover ticks, but they require a vet. For flea-only control at a low upfront cost, Advantage II does the job.
How does Advantage II differ from original Advantage?
Original Advantage contains only imidacloprid and kills adult fleas. Advantage II adds pyriproxyfen, an insect growth regulator that stops eggs and larvae from developing, so it also breaks the life cycle.
How long does one dose last and is it waterproof?
Each dose protects for 30 days. The formula is waterproof after 24 hours, so you can bathe the dog or let it swim after that window, but avoid wetting the spot for the first day.
Can I use Advantage II on cats or small dogs?
No. This box is for dogs 21-55 lbs only, and the product must never be used on cats. For dogs under 21 lbs or for cats, buy the matching size or species version.
What is in the box?
The box contains four monthly topical applicator tubes, a 4-month supply for one dog in the 21-55 lb range. There is no prescription and no other equipment included.
When is the best time to buy it?
Flea season drives prices up in spring and summer. Buying a 4-month box in fall or winter, or stocking up when a store runs a multi-box promotion, usually lands the lowest per-dose price.
Where is the Bayer Advantage II Flea Prevention for Dogs cheapest?
At Chewy.com, for $50.99, as of our latest check.
What do buyers say about the Bayer Advantage II Flea Prevention for Dogs?
Rated 3.6 out of 5 from 75 ratings.
Where can I buy the Bayer Advantage II Flea Prevention for Dogs?
6 stores we checked sell it, including Chewy.com, PetSmart, Centinela Feed & Pet Supplies, DoMyOwn.com, Amazon.

Shoppers also compared

  • E
    Elanco Seresto Flea and Tick Collar for Dogs
    Elanco Seresto Flea and Tick Collar for Dogs
  • B
    Boehringer Ingelheim Frontline Plus Flea and Tick Treatment for Dogs
    Boehringer Ingelheim Frontline Plus Flea and Tick Treatment for Dogs
  • A
    Advantix Dog 4 Month Topical Flea Treatment
    Advantix Dog 4 Month Topical Flea Treatment
  • F
    Flea & Tick Spot On for Dogs + Cats
    Flea & Tick Spot On for Dogs + Cats
  • K
    K9 Advantix II Flea and Tick Prevention for Dogs
    K9 Advantix II Flea and Tick Prevention for Dogs
  • A
    Advantage II for Dogs
    Advantage II for Dogs
  • F
    Frontline Plus for Dogs
    Frontline Plus for Dogs
  • P
    Peppermint Flea & Tick Spray for Pets + Home
    Peppermint Flea & Tick Spray for Pets + Home
Formulation Type
Topical Solution
Formulation
Waterproof (after 24 hours)
Lifecycle Targeted
Adult fleas, Eggs, Flea eggs, Flea larvae, Adults
Animal Type
Dogs
Treatment Type
Treatment, Prevention
Supply Duration
4 month supply
Supply Amount
6 count
Weight Range
21-55 lbs
Breed Restrictions
DO NOT USE ON CATS
Contains
Imidacloprid, Pyriproxyfen
Free Of
Fragrance
Package Type
Box
Scent
Fragrance-free