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Zoetis
Simparica Trio
Zoetis

Simparica Trio

Best price now

$234.77at AmazonObserved at 5:11 AM

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Our take on the Simparica Trio

Simparica Trio is Zoetis's monthly chewable for dogs that combines flea, tick, heartworm and intestinal worm protection in one tablet. It kills fleas within 4 to 8 hours and keeps killing for 35 days, and it kills 98.9% of paralysis ticks within 24 hours. It comes in weight bands from 1.25 kg to 60 kg and is labeled for puppies from 8 weeks old. The best new price is $234.77 at Amazon as of November 4, 2026, and only one store lists it new, so there is no cheaper new option to compare against right now.

Best forOwners who want one monthly chew instead of separate flea, tick and heartworm pr
Dogs from 8 weeks old, including puppies
Households with heavy tick exposure, including paralysis tick regions
Dogs that take chews readily
Pros
  • Covers fleas, ticks, heartworm and roundworm and hookworm in a single monthly dose
  • Fast flea kill, within 4 to 8 hours
  • 98.9% of paralysis ticks killed within 24 hours
  • Liver-flavored chew most dogs take as a treat
  • Wide weight range, from 1.25 kg to 60 kg
Cons
  • Prescription required in most markets
  • Monthly dosing means no long-acting protection if a dose is missed
  • Not for cats or for dogs under 8 weeks or under 1.25 kg
  • Some dogs vomit or drool after taking it
  • Only one new listing at $234.77, so little price competition

Simparica Trio prices at every store

  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $234.77Observed at 5:11 AM
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Also available at

  • Allivet Pet PharmacyCheck price at Allivet Pet Pharmacy
  • Tractor Supply CompanyCheck price at Tractor Supply Company

Simparica Trio price history

Lowest price we've seen: $43.48 on Nov 4 at Tractor Supply Company. Tracked across 3 stores since Nov 4.

What reviewers say

Owners generally report their dogs take the chew without fuss and that flea and tick protection holds through the month. The most common complaints are vomiting or drooling soon after dosing and the cost of keeping a large dog on it year-round.

Pros
  • Dogs accept the liver flavor
  • Effective flea and tick control
  • One chew replaces several products
Cons
  • Vomiting or drooling after dosing
  • Expensive for large dogs
  • Prescription hassle

Specifications

Animal
Dog
Minimum age
8 weeks of ageSource
Dosing frequency
one chew per monthSource
Flea kill speed
within 4 to 8 hoursSource
Sustained flea efficacy
35 daysSource
Paralysis tick kill
98.9% within 24 hoursSource
Form
Tasty liver flavoured chewSource
Weight range
1.25-2.5 kg to 40.1-60 kgSource
Sarolaner dose
0.54 mg/lb (1.2 mg/kg)Source
Moxidectin dose
0.011 mg/lb (24 μg/kg)Source
Pyrantel dose
2.27 mg/lb (5 mg/kg)Source
Administration
with or without foodSource

Questions and answers

Is Simparica Trio worth it over separate products?
For most owners, yes. One monthly chew covers fleas, ticks, heartworm and two intestinal worms, which is simpler and often cheaper than three separate products. The trade-off is that you cannot adjust each protection separately.
How does it compare with NexGard or Bravecto?
NexGard and Bravecto cover fleas and ticks but not heartworm, so you would add a heartworm preventive. Simparica Trio bundles heartworm and intestinal worm coverage into the same chew. Bravecto lasts 12 weeks for fleas and ticks; Simparica Trio is monthly.
How old does a puppy need to be?
At least 8 weeks old and at least 1.25 kg. Use the weight band that matches your puppy's current weight and recheck as it grows.
Can I give it with food?
Yes, with or without food. Give it as a chew or crumbled over food, and make sure the whole dose is swallowed.
Is $234.77 a good price?
It is the only new price listed as of November 4, 2026, so there is nothing cheaper to compare it with. Check the pack size against your dog's weight band, since the price per chew varies a lot by size.
Where is the Simparica Trio cheapest?
At Amazon, for $234.77, as of our latest check.
Where can I buy the Simparica Trio?
3 stores we checked sell it, including Amazon, Allivet Pet Pharmacy, Tractor Supply Company.

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