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Simparica Trio is a once-monthly chewable that combines flea, tick, heartworm and intestinal worm protection in one dose. It is the first combination product FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and it starts killing fleas within 4 hours. Vets prescribe it widely because it replaces separate flea/tick and heartworm products with a single liver-flavored chew most dogs take willingly. It suits owners who want broad, simple monthly coverage rather than stacking several preventives.
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Lowest price we've seen: $38.90 on Nov 15 at Tractor Supply Co; $39.47 now. Tracked across 9 stores since Nov 15.
Owners rate it highly, mostly for the convenience of one chew covering fleas, ticks and heartworm and for how readily dogs eat it. Complaints center on occasional stomach upset and the need for a vet prescription.
| Weight (lb.) | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | |
| 11-22 lb. | 12 | 0.24 | 50 | |
| 22-44 lb. | 24 | 0.48 | 100 | |
| 44-88 lb. | 48 | 0.96 | 200 | |
| 88-132 lb. | 72 | 1.44 | 300 |
Simparica Trio is a once-monthly, liver-flavored chewable tablet for dogs. It protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms.
It kills fleas before they can lay eggs. It starts killing fleas within 4 hours, and in studies it reached 100% effectiveness in 8 hours. It is the first combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections.
The tablet can be given with or without food. In a study, 9 out of 10 dogs took it voluntarily. The dose is based on the dog's weight. It is approved for puppies as young as eight weeks old that weigh at least the minimum weight.
