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Simparica Trio is a once-monthly liver-flavored chewable that combines heartworm prevention with flea and tick control and deworming in one dose. It kills fleas fast, is FDA-approved to kill six tick species including the deer tick, and also treats roundworms, hookworms and flea tapeworms. It suits owners who want to replace several separate preventatives with one chew. Against single-purpose products it covers more parasites per dose, though it requires a vet prescription and is not for dogs under 8 weeks or under 2.8 lb.
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Lowest price we've seen: $38.90 on Nov 15 at Allivet Pet Pharmacy. Tracked across 7 stores since Nov 15.
Owners rate it very highly and describe years of use with no fleas or ticks seen and no side effects. They like that a single monthly pill replaces several products and that dogs take it easily.
| Body Weight | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lbs | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lbs | 6.0 | 0.12 | 25 | 1 |
| 11-22 lbs | 12 | 0.24 | 50 | 1 |
| 22-44 lbs | 24 | 0.48 | 100 | 1 |
| 44-88 lbs | 48 | 0.96 | 200 | 1 |
| 88-132 lbs | 72 | 1.44 | 300 | 1 |
Simparica Trio is a monthly liver-flavored chewable tablet for dogs. It protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms. The active ingredients are sarolaner, moxidectin and pyrantel.
It kills fleas before they can lay eggs. In studies, it started killing fleas within 4 hours and reached 100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections. In a study, 9 out of 10 dogs voluntarily consumed it.
It is given by mouth once a month, with or without food. It is dosed by body weight and is approved for puppies 8 weeks and older that weigh at least 2.8 pounds. The FDA has authorized it under an Emergency Use Authorization to treat New World screwworm larvae (myiasis) in dogs and puppies. It is not approved for this use, and the authorization lasts only for the duration of the emergency declaration unless it is ended sooner.
