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FRONTLINE Plus is a monthly topical spot treatment for dogs 45–88 lbs that kills adult fleas, flea eggs, flea larvae, chewing lice and ticks. Its two active ingredients, fipronil and (S)-methoprene, attack both live fleas and the egg and larval stages, which is what separates it from single-ingredient flea drops. It is waterproof once dry and stays effective through swimming or bathing. Owners value the long track record and easy single-point application; the common complaints are that it is not a fast knockdown for a heavy existing infestation and that some dogs need a prescription-strength option instead.
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Lowest price we've seen: $40.98 on Nov 11 at Chewy. Tracked across 6 stores since Nov 11.
Owners rate it well overall and many have used it for years as their default monthly protection. The recurring complaints are slow results on a bad infestation, greasy or irritating spots on sensitive dogs, and the need to treat the whole house and every pet at once.
FRONTLINE Plus for Dogs is a topical flea and tick treatment for large breed dogs weighing 45 to 88 pounds. It kills fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. The formula contains fipronil and (S)-methoprene, which kill existing adult fleas, eggs, and larvae to help guard against further infestations.
The treatment is applied to a single point on the dog. It covers the whole body and deposits in the sebaceous glands, which act as a reservoir that continuously replenishes the treatment on the dog. It is waterproof and keeps working if the dog gets wet.
One dose each month protects against fleas and ticks for 30 days. It can be used on puppies as young as eight weeks old that weigh 5 pounds or more. All dogs or cats in the household should be treated monthly to control fleas and ticks and help prevent new flea infestations.
