
Simparica Trio Chewable Tablets for Dogs
Best price now
Compared across 4 stores. Prices are checked against each store and labelled with when.

Compared across 4 stores. Prices are checked against each store and labelled with when.
It checks today's price at every store, compares the alternatives and answers in about a minute.
Simparica Trio is a monthly prescription chewable from Zoetis that combines flea, tick, heartworm and intestinal worm protection in one dose. Its three active ingredients — sarolaner, moxidectin and pyrantel — make it the first FDA-approved combo preventative of its kind, and it kills fleas within four hours and is labeled against six tick species, including the deer tick linked to Lyme disease. It suits owners who want one monthly chew instead of separate flea, tick and heartworm products. Owners report it is easy to give and effective, though it is a vet prescription and not every dog takes the liver flavor willingly.
In stock
In stock
In stock
Availability unknown
As an Amazon Associate, Deal.ai earns from qualifying purchases.
Also available at
Store links may earn us a commission.
Lowest price we've seen: $209.00 on Nov 15 at ShotVet. Tracked across 9 stores since Nov 15.
Owners describe Simparica Trio as a convenient, effective monthly chew that has kept fleas, ticks and heartworm at bay, often for years. Many say their dogs take it without fuss and show no side effects.
| Body Weight | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lbs | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lbs | 6.0 | 0.12 | 25 | 1 |
| 11-22 lbs | 12 | 0.24 | 50 | 1 |
| 22-44 lbs | 24 | 0.48 | 100 | 1 |
| 44-88 lbs | 48 | 0.96 | 200 | 1 |
| 88-132 lbs | 72 | 1.44 | 300 | 1 |
Simparica Trio is a monthly liver-flavored chewable tablet for dogs. It protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms. It contains three active ingredients: sarolaner, moxidectin and pyrantel.
It starts killing fleas within 4 hours, reaching 100% effectiveness in 8 hours, and it kills fleas before they can lay eggs. It is the first combination preventative FDA-approved to kill six types of ticks, including the deer tick, which may carry Lyme infections. It is approved for puppies 8 weeks of age and older that weigh at least 2.8 lbs.
The tablet is given by mouth once a month, with or without food. Make sure your dog eats the complete dose and that none is lost or refused. If a dose is missed, give it right away and go back to monthly dosing. In a study, 9 out of 10 dogs took it voluntarily.






