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Simparica Trio is a once-monthly oral chew that combines three drugs — sarolaner, moxidectin and pyrantel — to protect dogs against fleas, ticks, heartworm disease, roundworms, hookworms and flea tapeworms. It is the first combination preventive FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and it starts killing fleas within 4 to 8 hours. It suits owners who want one chew instead of separate flea, tick and heartworm products, and it is approved for puppies from 8 weeks old. Owners and reviewers consistently call it easy to give and effective, though it is a prescription product and some dogs still need a vet check on suitability.
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Lowest price we've seen: $234.77 on Nov 15 at Amazon. Tracked across 2 stores since Nov 15.
Owners rate Simparica Trio highly and describe it as easy to give, with effective flea and tick protection.
Simparica Trio is a once-monthly chewable tablet for dogs that weigh 44.1 to 88 lbs (20 to 40 kg). It protects against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms. The liver-flavored chew can be given with or without food.
It starts killing fleas within 4 hours and kills them before they can lay eggs. It was the first combination preventative FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections. Puppies can take it from 8 weeks of age if they weigh at least 2.8 lbs (1.25 kg).
The FDA has authorized Simparica Trio under an Emergency Use Authorization to treat New World screwworm larvae (myiasis) in dogs and puppies. It is not approved for this use, and the authorization lasts only for the duration of the emergency declaration unless it is ended sooner.
