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Simparica Trio is a once-monthly liver-flavored chew that combines flea, tick, heartworm and intestinal worm protection in one dose. It kills adult fleas and treats and controls five tick species, prevents heartworm disease, and treats roundworm and adult hookworm. The single-chew format is simpler than pairing a flea and tick product with a separate heartworm preventive, which is why many owners stick with it. It is a prescription product for adult dogs, and reviewers rate it well overall while some report digestive upset or reluctance to eat the chew.
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Lowest price we've seen: $39.47 on Nov 15 at Amazon; highest $186.00 on Nov 14. Tracked across 9 stores since Nov 14.
Owners rate it 4.2 out of 5 and mostly praise the convenience of one monthly chew covering fleas, ticks, heartworm and worms. Complaints center on dogs refusing the flavor and occasional stomach upset after dosing.
Simparica Trio is a once-a-month, liver-flavored chewable tablet for dogs. One chew prevents heartworm disease and treats and controls fleas, ticks, roundworms and hookworms.
It kills adult fleas and treats and prevents flea infestations. It also helps control flea allergy dermatitis. For ticks, it treats and controls lone star, Gulf Coast, American dog, black-legged and brown dog ticks.
It is for dogs and puppies 8 weeks of age and older.











