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Simparica
Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green

Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green

4.9(116 ratings)

Best price now

$85.00at Smartway Pet SuppliesChecked 13 h ago

Compared across 2 stores. Prices are checked against each store and labelled with when.

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Price facts

  • Lowest price today: $85.00 at Smartway Pet Supplies (checked Nov 15, 2026).
  • Checked at 2 stores.

Our take on the Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green

Simparica Trio is a monthly oral chew that combines three drugs: sarolaner for fleas and ticks, moxidectin for heartworm prevention and hookworms, and pyrantel for roundworms. One liver-flavored chew covers fleas, six tick species including deer ticks, heartworm disease, roundworms and hookworms, which is more than most single-parasite products offer. It suits large dogs from 44.3 to 88 lbs and puppies from 8 weeks old. Owners report dogs take the chew readily and that flea and tick control holds up well.

Best forLarge-breed owners wanting one monthly chew for fleas, ticks, heartworm and wormDogs that refuse topical treatmentsMulti-dog households on a simple monthly routinePuppies from 8 weeks old in the weight range
Pros
  • Three active ingredients cover fleas, ticks, heartworm and two intestinal worms in one dose
  • Kills fleas within 4 to 8 hours and keeps killing for 35 days
  • Kills 98.9% of existing paralysis ticks within 24 hours
  • Liver-flavored chew most dogs take without fuss
  • Can be given with or without food
  • Monthly dosing is simpler than mixing separate products
Cons
  • Prescription-only in most US states, so a vet visit is needed
  • Not for dogs under 44.3 lbs or under 8 weeks old
  • Does not cover tapeworms
  • Some dogs may vomit or drool after dosing
  • No protection against mites or lice

Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green prices at every store

  • Smartway Pet SuppliesNew

    In stockReturn policy

    $85.00Checked 13 h ago
    Visit Smartway Pet Supplies
  • AmazonNew

    Availability unknown

    As an Amazon Associate, Deal.ai earns from qualifying purchases.

    $234.77Checked 15 h ago
    Visit Amazon

Also available at

  • 79Pets.comCheck price at 79Pets.com

Store links may earn us a commission.

Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green price history

Lowest price we've seen: $234.77 on Nov 15 at Amazon. Tracked across 1 store since Nov 15.

What reviewers say

  • 4.9 / 5116 ratings

Rated 4.9 out of 5 from 116 ratings. Buyers say the chew is easy to give and dogs tolerate it, and that flea and tick protection is effective.

What people mention
  • PalatabilityPraisedBuyers say dogs take the liver-flavored chew without trouble.
  • EfficacyPraisedOwners report strong flea and tick control.
  • ValuePraisedBuyers consider the coverage good value for a monthly chew.

From 79Pets.com

  • Monthly chewable providing complete parasite protection for dogs 44.1–88 lbs (20–40 kg)
  • Protects against fleas, ticks, heartworms, roundworms and hookworms
  • Convenient once-a-month chewable tablet
  • Fast-acting formula that kills fleas and ticks
  • Helps prevent heartworm disease
  • Treats and controls intestinal worms
Materials
Active ingredients per tablet: Sarolaner 48 mg, Moxidectin 0.96 mg, Pyrantel 200 mg
Sizing
For dogs weighing 44.1–88 lbs (20–40 kg); suitable for puppies 8 weeks and older weighing at least 2.8 lbs (1.25 kg)
Packs
3 Pack

About the Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green

Simparica Trio is a monthly chewable for dogs weighing 44.3–88 lbs (20.1–40 kg). One liver-flavored chew helps prevent heartworm disease, kills fleas and ticks, and treats and controls roundworms and hookworms.

The chew combines three active ingredients. Sarolaner kills fleas and ticks. Moxidectin prevents heartworm larvae from developing. Pyrantel paralyzes intestinal roundworms and hookworms so they pass out of the dog's system. It kills adult fleas starting at 4 hours after dosing and kills the fleas that carry flea tapeworm. It also protects against six tick species, including the black-legged (deer) tick, and helps prevent infections that may cause Lyme disease.

Give one chew each month, with or without food, and make sure the dog eats the whole chew. It can be given from 8 weeks of age, and year-round dosing keeps protection continuous.

Animal
Dogs
Dog weight
44.3–88 lbs (20.1–40 kg)
Minimum age
8 weeks
Active ingredients
Per tablet: sarolaner 48 mg, moxidectin 0.96 mg, pyrantel 200 mg
Dosing
One chew per month, with or without food
Administration
Oral
Flavor
Liver
Tablet
Reddish brown, pentagon-shaped with rounded edges, 9 mm
Flea control
Starts killing fleas within 4 to 8 hours; effective for 35 days
Tick control
98.9% of pre-existing paralysis ticks killed within 24 hours; 30-day protection against six tick species
Tick species
Lone Star, Gulf Coast, American dog, black-legged (deer), brown dog and Asian longhorned ticks

What buyers say

Buyers like
  • Easy to give and dogs tolerate the chew
  • Effective flea and tick protection
  • Good price and value
  • Fast, consistent shipping
  • Good customer service and issue resolution
  • Authentic quality products
Buyers complain about
  • Shipping takes longer since it ships from abroad
  • Delivery is not fast

Specifications

Active ingredients
sarolaner, moxidectin, and pyrantelSource
Route of administration
ORALSource
Tablet color
brown (reddish brown)Source
Tablet shape
PENTAGON (5 sided) (rounded edges)Source

Questions and answers

What does Simparica Trio protect against?
It prevents heartworm disease and treats and controls fleas, six tick species including deer ticks, roundworms and hookworms. It does not cover tapeworms.
How often is it given?
One chew per month. It can be given with or without food.
Which dogs is the green chew for?
Dogs weighing 44.3 to 88 lbs (20.1 to 40 kg), from 8 weeks of age. Smaller dogs need a different strength.
How fast does it kill fleas and ticks?
Fleas are killed within 4 to 8 hours, and flea efficacy lasts 35 days. It kills 98.9% of existing paralysis ticks within 24 hours.
Do I need a prescription?
Simparica Trio is prescription-only in most US states, so your vet needs to authorize it. Heartworm testing is advised before starting in dogs not already on prevention.
What is in the box?
Chews of the green large-dog strength, dosed by weight. Check the pack count against how many months you need.
Where is the Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green cheapest?
At Smartway Pet Supplies, for $85.00, as of our latest check.
What do buyers say about the Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green?
Rated 4.9 out of 5 from 116 ratings. Buyers like: Easy to give and dogs tolerate the chew; Effective flea and tick protection; Good price and value. Common complaints: Shipping takes longer since it ships from abroad; Delivery is not fast.
Where can I buy the Simparica Trio Chewables For Large Dogs 44.3–88lbs (20.1-40Kg) Green?
3 stores we checked sell it, including Smartway Pet Supplies, Amazon, 79Pets.com.

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Heartworm
Helps prevent heartworm disease
Intestinal worms
Roundworms and hookworms
Tablet size
9mmSource
Minimum age
8 weeks of ageSource
Dosing frequency
one chew per monthSource
Flea kill speed
within 4 to 8 hours after treatmentSource
Flea efficacy duration
35 daysSource
Paralysis tick kill rate
98.9% of pre-existing paralysis ticks killed within 24 hoursSource
Flavor
liver flavoured chewSource
Administration with food
with or without foodSource
Animal
Dog
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