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Simparica Trio is a monthly oral chew that combines three drugs: sarolaner for fleas and ticks, moxidectin for heartworm prevention and hookworms, and pyrantel for roundworms. One liver-flavored chew covers fleas, six tick species including deer ticks, heartworm disease, roundworms and hookworms, which is more than most single-parasite products offer. It suits large dogs from 44.3 to 88 lbs and puppies from 8 weeks old. Owners report dogs take the chew readily and that flea and tick control holds up well.
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Lowest price we've seen: $234.77 on Nov 15 at Amazon. Tracked across 1 store since Nov 15.
Rated 4.9 out of 5 from 116 ratings. Buyers say the chew is easy to give and dogs tolerate it, and that flea and tick protection is effective.
Simparica Trio is a monthly chewable for dogs weighing 44.3–88 lbs (20.1–40 kg). One liver-flavored chew helps prevent heartworm disease, kills fleas and ticks, and treats and controls roundworms and hookworms.
The chew combines three active ingredients. Sarolaner kills fleas and ticks. Moxidectin prevents heartworm larvae from developing. Pyrantel paralyzes intestinal roundworms and hookworms so they pass out of the dog's system. It kills adult fleas starting at 4 hours after dosing and kills the fleas that carry flea tapeworm. It also protects against six tick species, including the black-legged (deer) tick, and helps prevent infections that may cause Lyme disease.
Give one chew each month, with or without food, and make sure the dog eats the whole chew. It can be given from 8 weeks of age, and year-round dosing keeps protection continuous.














