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Simparica Trio is a monthly oral chew that combines three drugs in one tablet: sarolaner for fleas and ticks, moxidectin for heartworm prevention and hookworm and roundworm control, and pyrantel for additional intestinal worm coverage. It is FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and it starts killing fleas within four hours. The liver-flavored chew is built for dogs that take pills easily, and most dogs in the maker's study ate it voluntarily. It competes with spot-on and separate-tablet routines by replacing them with one dose a month, though it requires a vet prescription and does not cover tapeworms directly.
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Lowest price we've seen: $44.63 on Nov 15 at Tractor Supply Co. Tracked across 2 stores since Nov 15.
Owners and vets describe Simparica Trio as a convenient all-in-one monthly preventive that dogs accept well. Buyers report fast flea kill and reliable tick control, and many switched from combining a flea product with a separate heartworm pill.
| Weight (lb.) | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | |
| 11-22 lb. | 12 | 0.24 | 50 | |
| 22-44 lb. | 24 | 0.48 | 100 | |
| 44-88 lb. | 48 | 0.96 | 200 | |
| 88-132 lb. | 72 | 1.44 | 300 |
This is a monthly liver-flavored chewable tablet for dogs weighing 44.1 to 88 lbs. It protects against heartworms, ticks, fleas, and intestinal worms. Each tablet contains sarolaner, moxidectin, and pyrantel.
It kills fleas before they can lay eggs. It starts killing fleas within 4 hours and reaches 100% effectiveness in 8 hours. It is FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections. It treats and controls roundworms and hookworms, and it prevents tapeworms by killing fleas.
The tablet is given by mouth once a month, with or without food. It is dosed by weight, so this size is for dogs in the 44.1 to 88 lb range. In a study, 9 out of 10 dogs voluntarily consumed it.
