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Simparica Trio is a monthly oral parasite preventive for dogs that combines three active ingredients: sarolaner for fleas and ticks, moxidectin for heartworms and hookworms, and pyrantel for roundworms and hookworms. One chew covers flea and tick control, heartworm prevention and treatment of intestinal worms, which replaces stacking separate products. It is FDA-approved to kill six tick species, including the deer tick that can carry Lyme disease, and it kills fleas before they lay eggs. The pork-liver chew is eaten willingly by most dogs in studies, and owners often switch to it when other preventatives failed or were hard to give. It requires a prescription and is dosed by weight band, so the 44.1-88 lb tablets fit medium and large dogs.
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Lowest price we've seen: $44.63 on Nov 15 at Tractor Supply Co. Tracked across 5 stores since Nov 15.
Owners largely report that Simparica Trio works well, with many saying it cleared flea and tick problems that other preventatives missed. Most dogs eat the chew without a fight, and many reviewers saw no adverse effects. Complaints center on cost and on the occasional dog that still picks up ticks or reacts to the dose.
Simparica Trio is a monthly chewable tablet for dogs that protects against heartworms, ticks, fleas and intestinal worms. It contains sarolaner, moxidectin and pyrantel (as pamoate salt). This box is for dogs weighing 44.1-88 lbs and holds six chews.
It kills fleas before they lay eggs, which prevents flea infestations. It is FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme disease. It treats and controls roundworms and hookworms, and it prevents tapeworms by killing fleas. In studies supporting FDA approval, one dose provided 100% protection against heartworm disease.
The chew is pork liver flavored, and 91.9% of dogs voluntarily ate it in a study. It is given by mouth once a month and is dosed by weight. It is approved for puppies as young as 8 weeks that weigh at least 2.8 lbs. The chews are not scored.
