Is Simparica Trio on Sale? November 2026

Buying guides that pick Simparica Trio

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  Buying guide · 8 picksBest flea, tick and heartworm prevention for dogs

More Simparica Trio prices

• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 11.1-22 lbs$210.09 at BaxterBooVisit BaxterBoo
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 44.1-88 lbs, 3 doses$234.77 at AmazonVisit Amazon
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 11.1-22 lbs, 1-Month Supply$40.05 at AmazonVisit Amazon
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 44.1-88 lbs, 6 doses$234.77 at BaxterBooVisit BaxterBoo
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs$43.48 at Tractor Supply CoVisit Tractor Supply Co
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 5.6-11 lbs, 1-Month Supply$43.48 at Tractor Supply CoVisit Tractor Supply Co
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 22.1-44 lbs$43.48 at Tractor Supply CoVisit Tractor Supply Co
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 44.1-88 lbs, 1 dose$44.63 at Tractor Supply CoVisit Tractor Supply Co
• Simparica Trio

  
  Simparica Trio Chewable Tablets for Dogs, 44.1-88 lbs, 1 treatment$44.63 at Tractor Supply CoVisit Tractor Supply Co

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Questions and answers

What does Simparica Trio protect against?

Each monthly chewable kills fleas and ticks, prevents heartworm disease, and treats and controls roundworms and hookworms. It also treats existing flea and tick infestations. It does not cover tapeworms, whipworms, or mites.

How is Simparica Trio given, and at what age can dogs start it?

It is a flavored chew given once a month, with or without food. It is approved for dogs 8 weeks and older weighing at least 2.8 pounds, and it comes in weight-band sizes, so match the tablet to the dog's current weight.

What are the common side effects?

The most reported effects are vomiting, diarrhea, lethargy, and decreased appetite. Serious reactions are uncommon. Talk to your vet before use in dogs with a history of seizures or neurological disorders, and for dogs on other heartworm prevention.

Does Simparica Trio require a heartworm test first?

Dogs should be tested for existing heartworm infection before starting any heartworm preventive, including this one. Vets also often recommend a negative test before switching from another preventive.

How does it compare with giving separate flea, tick, and heartworm products?

One chew replaces a flea and tick product plus a heartworm preventive plus a dewormer, which cuts the number of doses and the chance of missing one. The trade-off is that it covers only the parasites in its label, so tapeworm and whipworm control needs a separate product.

Are there Simparica Trio discount codes?

Deal.ai checks what Simparica Trio products actually cost at every store, so a real markdown shows on this page as a deal as soon as it starts, and each product's page has its price history to tell a sale from its usual price.