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Simparica Trio is a once-monthly oral chew that combines flea, tick, heartworm, roundworm, hookworm and tapeworm protection in one tablet. It is the first combination product FDA-approved to kill six tick species, including the deer tick linked to Lyme disease, and it starts killing fleas within 4 hours. The liver-flavored chew suits dogs that take pills easily, and most dogs in a study ate it voluntarily. It competes with spot-on and separate-tablet routines by replacing several products with one dose, though it requires a prescription and a weight-matched tablet.
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Lowest price we've seen: $210.09 on Nov 15 at Tractor Supply Co. Tracked across 5 stores since Nov 15.
Owners rate it highly and mostly praise the convenience of one monthly chew covering fleas, ticks and worms. Many say their dogs eat it without fuss. A minority report stomach upset or reluctance after the first dose.
| Weight (lb.) | Sarolaner per Tablet (mg | Moxidectin per Tablet (m | Pyrantel per Tablet (mg) | Number of Tablets Admini |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | 1 |
| 11-22 lb. | 12 | 0.24 | 50 | 1 |
| 22-44 lb. | 24 | 0.48 | 100 | 1 |
| 44-88 lb. | 48 | 0.96 | 200 | 1 |
| 88-132 lb. | 72 | 1.44 | 300 | 1 |
Simparica Trio is a once-monthly, liver-flavored chewable tablet for dogs. It combines protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms and hookworms in one dose. This size is for dogs weighing 11.1 to 22 lbs.
It starts killing fleas within 4 hours and kills fleas before they can lay eggs. It is FDA-approved to kill six types of ticks, including the deer tick that may carry Lyme infections. It can be given with or without food, and 9 out of 10 dogs voluntarily consumed it in a study.
Each dose is based on the dog's weight. It is approved for puppies 8 weeks of age and older who weigh at least the minimum weight for the size.
